1. You got me all bent out of shape.
2. That gives me the hump.
3. The news completely upset him.
4. The child's screams jarred my nerves.
5. That man really bugs me.
6. It's getting on my nerves.
7. The noise was maddening.
8. His questions drove me to distraction.
9. The bad news bothered me.
10. I felt harassed by all the work at the office.